How to prevent senile fading memory

A new way to prevent senile fading memory, scientists have found a
MOSCOW, May 7 - RIA Novosti. Scientists have identified molecular changes in brain cells that lead to senile problems with memory in mice, and developed a technique for restoring the brain's ability to remember, according to the article the researchers published in the journal Science on Friday.
The new technique may in future be used for the treatment of disorders of memory in humans.
The work of a group of scientists led by Andre Fisher (Andre Fischer) of the European Institute of Neuroscience in Göttingen, Germany, focused on the so-called histone - protein molecules that assist of nuclear DNA to pack itself in the chromosome. The influence of these proteins on memory performance have been identified in previous studies. Scientists have reasonably believed that the changes in these proteins, the aging of the organism, in some way affect the work of genes responsible for growth and activity of neurons involved in memory performance.
To find out what is this effect, the researchers used the experimental mice, who were to learn to navigate in a new space for them. Mice were placed in special mazes, hit the part of the "rooms" which leads to the fact that the mice received a small electric shock. Brought in the experiment, young mice aged three months, quickly learned to avoid these rooms, which was accompanied by activation of about 1,5 thousands of genes in their DNA, responsible for the synthesis of proteins that help the growth of new neurons - a key process of working memory in animals and humans.
A similar experiment with a 16-month-old mice, this activation of genes they have not shown that was accompanied by a significantly lower ability of subjects to remember the dangerous room.
With Fisher analyzed the difference in the structure of the chromosomes of young and old mice involved in the study and found that in young mice, there is chemical modification of histone in the region of DNA where the genes responsible for the work of memory and learning. This chemical modification is to join the protein molecule so-called acetyl groups - SOSN3, which apparently activates genes.
In old mice, this acetylation was not observed, but researchers were able to run it artificially, introducing an enzyme in mice, causing acetylation of histones in various positions, including that which relates to the work of memory genes. Shortly thereafter, the old mice began to cope with the problem of orientation in space is no worse than their younger counterparts.
The study authors suggest that a similar mechanism of extinction memory in old age also works in humans, at this point has not yet published data on the study of chromosomes in the brain of patients with Alzheimer's disease.
Scientists believe that the development of new drugs, triggering histone acetylation in the brain cells of elderly people, help them regain control over their memory.
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The new technique may in future be used for the treatment of disorders of memory in humans.
The work of a group of scientists led by Andre Fisher (Andre Fischer) of the European Institute of Neuroscience in Göttingen, Germany, focused on the so-called histone - protein molecules that help nuclear DNA to pack itself in the chromosome. The influence of these proteins on memory performance have been identified in previous studies. Scientists have reasonably believed that the changes in these proteins, the aging of the organism, in some way affect the work of genes responsible for growth and activity of neurons involved in memory performance.
To find out what is this effect, the researchers used the experimental mice, who were to learn to navigate in a new space for them. Mice were placed in special mazes, hit the part of "rooms" which leads to the fact that mice receiving a small electric shock. Brought in the experiment, young mice aged three months, quickly learned to avoid these rooms, which was accompanied by activation of about 1,5 thousands of genes in their DNA, responsible for the synthesis of proteins that help the growth of new neurons - a key process of working memory in animals and humans.
A similar experiment with a 16-month-old mice, this activation of genes they have not shown that was accompanied by a significantly lower ability of subjects to remember the dangerous room.
With Fisher analyzed the difference in the structure of the chromosomes of young and old mice involved in the study and found that in young mice, there is chemical modification of histone in the region of DNA where the genes responsible for the work of memory and learning. This chemical modification is to join the protein molecule so-called acetyl groups - SOSN3, which apparently activates genes.
In old mice, this acetylation was not observed, but researchers were able to run it artificially, introducing an enzyme in mice, causing acetylation of histones in various positions, including that which relates to the work of memory genes. Shortly thereafter, the old mice began to cope with the problem of orientation in space is no worse than their younger counterparts.
The study authors suggest that a similar mechanism of extinction memory in old age also works in humans, at this point has not yet published data on the study of chromosomes in the brain of patients with Alzheimer's disease.
Scientists believe that the development of new drugs, triggering histone acetylation in the brain cells of elderly people, help them regain control over their memory.